Senior Medical Director, Rheumatology

Company: Alumis Inc.
Location: South San Francisco
Posted on: January 18, 2026

Job Description:

Alumis Inc. is a precision medicines company with the mission to transform the lives of patients with autoimmune diseases. Even with treatment innovations of the last two decades, many patients with immunologic conditions continue to suffer - our goal is to fundamentally change the outcomes for these patients. We are seeking an experienced Senior Medical Director in Clinical Development who will be involved across the full scope of rheumatology and autoimmune clinical drug development activities from discovery research through first in human, POC, and Phase 3 studies. The role will include leadership of one or more studies within the portfolio and will work closely with all members of the cross-functional asset team, to apply full clinical knowledge to successfully advance clinical programs as well as the overall asset strategy. Principal Responsibilities Serve as the physician lead for LUMUS, a 388-patient Phase 2b clinical trial designed to evaluate the efficacy, safety, and pharmacokinetics of multiple doses of ESK-001 in adult patients with moderately to severely active, autoantibody-positive SLE. Provide leadership of in-stream data reviews and reconciliation efforts. Hold authorship of clinical portions of key study documents, such as Protocol Amendments and Regulatory Submissions. Provide oversight of the LUMUS medical monitor. • Participates in external scientific engagement, including peer-to-peer interactions with MDs. Broadly represent the interests of Alumis as a leader, supporting corporate initiatives across rheumatology. Coach, manage, inspire, and support team members to achieve goals by leveraging a focused and collaborative mindset. Maintain the highest levels of integrity and standards for scientific inquiry in drug development. Primary Goals During the opening months on the job, this Senior Medical Director will be expected to focus on the following objectives: 1. Earn the full trust and respect of key internal and external stakeholders by establishing a reputation as a strategic and highly productive partner. 2. Provide hands-on leadership, apply knowledge and expertise, and partner seamlessly with the operations team to help make LUMUS thrive. 3. Focus on improving and maintaining study data quality, including cross-referencing of the main efficacy endpoints. Candidate Requirements MD (or ex-US equivalent) with board certification in Rheumatology. 5 years of clinical development experience; having a background in lupus clinical trials is desired. Proven leadership skills, as evidenced by having managed people within a pharmaceutical company or in a clinical/academic environment. Ability to assess, understand, and communicate continuously expanding medical and scientific information. Proven professional track record of strategic, organizational, and executional skills to support project planning across multiple activities, with the ability to anticipate and prioritize one’s workload across multiple projects of equal importance. Proven ability to approach deliverables in an organized manner with attention to detail and to meet timelines in a fast-paced environment. Established ability to work across diverse teams in a matrixed organizational structure, both as a leader and as part of a cross-functional team. Strong interpersonal, influencing, presentation, and communications skills (both written and verbal) to effectively address all levels within an organization. Ability to work autonomously and with a high level of independence. Willingness to travel to Alumis’ HQ in South San Francisco for one week out of every month The salary range for this position is $300,000 USD to $358,000 USD annually. This salary range is an estimate, and the actual salary may vary based on the Company’s compensation practices. This position is located in South San Francisco, CA and employees are expected to be onsite Tuesday-Thursday. Open to remote applicants with requirement to be onsite once a month. Alumis Inc. is an equal opportunity employer. Alumis compensation packages include generous stock option grants for all employees as well as an annual bonus program. Other benefits include: Health insurance premiums paid at 90% for employee, 80% for dependents Free access to Genentech Bus & Ferry Share program $100 monthly cell phone stipend Unlimited PTO for Exempt employees Free onsite gym and a kitchen stocked with yummy snacks and drinks! We are a hard-working, collaborative team on a mission to transform patient’s lives and we aspire to elevate , challenge and nurture one another along the way.

Keywords: Alumis Inc., Napa , Senior Medical Director, Rheumatology, Healthcare , South San Francisco, California